Issue 18, 2018

Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant

Abstract

The chromanone scaffold is considered as a privileged structure in drug discovery. Herein, we report a highly efficient PhI(OAc)2 mediated regioselective, direct C–H hydroxylation of chromanones. This method offers easy access to substituted 6-hydroxy chromanones in moderate to good isolated yields, thus paving the way for their pharmaceutical studies.

Graphical abstract: Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2017
Accepted
01 Feb 2018
First published
01 Feb 2018

Chem. Commun., 2018,54, 2252-2255

Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant

N. Viswanadh, G. S. Ghotekar, M. B. Thoke, R. Velayudham, A. C. Shaikh, M. Karthikeyan and M. Muthukrishnan, Chem. Commun., 2018, 54, 2252 DOI: 10.1039/C7CC08588E

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