Three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds

Abstract

This report describes a new method for three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds via air-stable SCF₃ and SeCF₃ reagents as free-radical initiators of ethyl iododifluoroacetate. β-Proton elimination can be overcome effectively in this reaction system, and a broad substrate scope, including alkenes and alkynes, makes this approach practical and attractive.