An enzymatic advance in nicotine cessation therapy

Song Xue; Marsida Kallupi; Bin Zhou; Lauren C. Smith; Pedro O. Miranda; Olivier George; Kim D. Janda

doi:10.1039/C7CC09134F

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An enzymatic advance in nicotine cessation therapy†

Song Xue,

‡^a Marsida Kallupi,

‡^b Bin Zhou,^a Lauren C. Smith,

^a Pedro O. Miranda,

^a Olivier George

^b and Kim D. Janda

*^ac

Author affiliations

* Corresponding authors

^a Departments of Chemistry, Immunology, Microbiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
E-mail: kdjanda@scripps.edu

^b Department of Neuroscience, The Scripps Research Institute, La Jolla, California 92037, USA

^c Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA

Abstract

A nicotine-degrading enzyme termed NicA2 was altered (NicA2-J1) through fusion of an albumin binding domain to increase its half-life. Examination of NicA2-J1 in vivo demonstrated a complete blockade of brain nicotine access, which in turn blunted nicotine's psychoactive effects. These data further support development of pharmacokinetic nicotine cessation therapeutics.

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Article information

DOI: https://doi.org/10.1039/C7CC09134F
Article type: Communication
Submitted: 28 Nov 2017
Accepted: 28 Dec 2017
First published: 02 Jan 2018

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Chem. Commun., 2018,54, 1686-1689

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An enzymatic advance in nicotine cessation therapy

S. Xue, M. Kallupi, B. Zhou, L. C. Smith, P. O. Miranda, O. George and K. D. Janda, Chem. Commun., 2018, 54, 1686 DOI: 10.1039/C7CC09134F

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Chemical Communications

An enzymatic advance in nicotine cessation therapy†

Abstract

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An enzymatic advance in nicotine cessation therapy

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