Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

Sirong Shi; Shiyu Lin; Yong Li; Tao Zhang; Xiaoru Shao; Taoran Tian; Tengfei Zhou; Qianshun Li; Yunfeng Lin

doi:10.1039/C7CC09397G

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes†

Sirong Shi,^a Shiyu Lin,^a Yong Li,^b Tao Zhang,^a Xiaoru Shao,^a Taoran Tian,^a Tengfei Zhou,^a Qianshun Li^a and Yunfeng Lin

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China
E-mail: yunfenglin@scu.edu.cn
Fax: +86-28-85582167
Tel: +86-28-85503487

^b Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Southwest Medical University, Luzhou 646000, China

Abstract

Tetrahedral DNA nanostructures (TDNs) have gathered great attention and are being widely used in biomedicine. We demonstrated that autophagy increased after exposure to TDNs (250 nM) along with the up-regulation of several autophagy-related genes and proteins. TDNs enhanced cell autophagy through the PI3K/AKT/mTOR signaling pathway.

Download options Please wait...

Supplementary files

Supplementary information PDF (723K)

Article information

DOI: https://doi.org/10.1039/C7CC09397G
Article type: Communication
Submitted: 07 Dec 2017
Accepted: 02 Jan 2018
First published: 02 Jan 2018

Download Citation

Chem. Commun., 2018,54, 1327-1330

Permissions

Request permissions

Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

S. Shi, S. Lin, Y. Li, T. Zhang, X. Shao, T. Tian, T. Zhou, Q. Li and Y. Lin, Chem. Commun., 2018, 54, 1327 DOI: 10.1039/C7CC09397G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

Social activity

Search articles by author

Spotlight

Advertisements