Issue 20, 2018
From the journal:

Chemical Communications

Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly†

Jintong Liu,a   Ping Du,a   Jing Zhang,*b   Hong Shena  and  Jianping Lei ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: jpl@nju.edu.cn

b School of Petrochemical Engineering, School of Food Science and Technology, Changzhou University, Changzhou 213164, China
E-mail: jzhang@cczu.edu.cn

Abstract

A flowerlike nanovector is developed for the fluorescence imaging and detection of miRNA in live cells with catalytic hairpin assembly. This horned vector provides a high loading efficiency of DNA amplifiers for multiple signal outputs and is applied to detect miRNA-21 in an average single HeLa cell, showing promising application in trace detection of intracellular biomolecules.

Graphical abstract: Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

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Article information

DOI
https://doi.org/10.1039/C7CC09579A
Article type
Communication
Submitted
14 Dec 2017
Accepted
12 Feb 2018
First published
12 Feb 2018

Chem. Commun., 2018,54, 2550-2553

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Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

J. Liu, P. Du, J. Zhang, H. Shen and J. Lei, Chem. Commun., 2018, 54, 2550 DOI: 10.1039/C7CC09579A

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