Issue 22, 2018
From the journal:

Chemical Communications

Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles†

Isabel Abánades Lázaro,a   Sandra Abánades Lázaroa  and  Ross S. Forgan ORCID logo *a  

* Corresponding authors

a WestCHEM, School of Chemistry, University of Glasgow, University Avenue, Glasgow, UK
E-mail: Ross.Forgan@glasgow.ac.uk

Abstract

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

Graphical abstract: Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

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Article information

DOI
https://doi.org/10.1039/C7CC09739E
Article type
Communication
Submitted
20 Dec 2017
Accepted
22 Feb 2018
First published
22 Feb 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 2792-2795

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Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

I. Abánades Lázaro, S. Abánades Lázaro and R. S. Forgan, Chem. Commun., 2018, 54, 2792 DOI: 10.1039/C7CC09739E

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