Intermolecular chemo- and regioselective aromatic C–H amination of alkoxyarenes promoted by rhodium nitrenoids

Abstract

Intermolecular aromatic C(sp²)–H amination promoted by neutral rhodium nitrenoids has been developed. The reactions proceeded with various oxygen-substituted arenes (1.5 equiv.) in a chemo- and regioselective manner. The aromatic C(sp²)–H amination took place at the para position of the oxygen substituent in the presence of benzylic C(sp³)–H bonds and/or C(sp³)–H bonds α to ethereal oxygen.