Issue 20, 2018
From the journal:

Chemical Communications

A simple “mix-and-detection” method for the sensitive detection of telomerase from cancer cells under absolutely isothermal conditions†

Fei Ma,‡a   Shu-hua Wei,‡a   Junhong Leng,‡b   Bo Tang ORCID logo *a  and  Chun-yang Zhang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China
E-mail: cyzhang@sdnu.edu.cn, tangb@sdnu.edu.cn
Fax: +86 0531-82615258
Tel: +86 0531-86186033

b Jinan Maternity and Child Care Hospital, Jinan 250000, China

Abstract

We develop a simple “mix-and-detection” method for the sensitive detection of telomerase from cancer cells under absolutely isothermal conditions. This method enables one-step and one-tube detection of telomerase with a detection limit of 3 cells, and it can be further applied for the screening of telomerase inhibitors and the discrimination of cancer cells from normal cells.

Graphical abstract: A simple “mix-and-detection” method for the sensitive detection of telomerase from cancer cells under absolutely isothermal conditions

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Article information

DOI
https://doi.org/10.1039/C8CC00093J
Article type
Communication
Submitted
05 Jan 2018
Accepted
31 Jan 2018
First published
31 Jan 2018

Chem. Commun., 2018,54, 2483-2486

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A simple “mix-and-detection” method for the sensitive detection of telomerase from cancer cells under absolutely isothermal conditions

F. Ma, S. Wei, J. Leng, B. Tang and C. Zhang, Chem. Commun., 2018, 54, 2483 DOI: 10.1039/C8CC00093J

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