Issue 29, 2018

Biotin-functionalized targeted polydiacetylene micelles

Abstract

Polydiacetylene micelles were functionalized with controlled amounts of biotin using bioorthogonal click chemistry. The biotinylated micelles were evaluated in the selective targeting of the MCF-7 cancerous cell line and were shown to be readily internalized. The efficiency of the cellular uptake was correlated to the density of grafted biotin.

Graphical abstract: Biotin-functionalized targeted polydiacetylene micelles

Supplementary files

Article information

Article type
Communication
Submitted
23 Jan 2018
Accepted
19 Mar 2018
First published
19 Mar 2018

Chem. Commun., 2018,54, 3613-3616

Biotin-functionalized targeted polydiacetylene micelles

A. Doerflinger, N. N. Quang, E. Gravel, G. Pinna, M. Vandamme, F. Ducongé and E. Doris, Chem. Commun., 2018, 54, 3613 DOI: 10.1039/C8CC00553B

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