Issue 37, 2018
From the journal:

Chemical Communications

Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery†

Mingtao Tao,a   Keming Xu,a   Suyun He,a   Hongmei Li,b   Li Zhang,a   Xuefang Luo*a  and  Wenying Zhong ORCID logo *ab  

* Corresponding authors

a Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China

b Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, P. R. China
E-mail: xfluo@cpu.edu.cn, wyzhong@cpu.edu.cn

Abstract

A novel forky peptide was designed and synthesized. The peptide self-assembled into supramolecular hydrogels triggered by zinc ions (ZIs). The hydrogels were designed for a drug delivery system (DDS), loaded with docetaxel and applied for the therapy of prostate cancer. In this research, we have discussed the response mechanism and evaluated the anticancer effect of the DDS.

Graphical abstract: Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery

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Article information

DOI
https://doi.org/10.1039/C8CC00604K
Article type
Communication
Submitted
24 Jan 2018
Accepted
09 Apr 2018
First published
10 Apr 2018

Chem. Commun., 2018,54, 4673-4676

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Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery

M. Tao, K. Xu, S. He, H. Li, L. Zhang, X. Luo and W. Zhong, Chem. Commun., 2018, 54, 4673 DOI: 10.1039/C8CC00604K

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