Issue 36, 2018

Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells

Abstract

Size-dependent uptake behaviors of electrically neutral amphipathic polymeric nanoparticles in cell-sized liposomes and living cells were investigated. Kinetic analyses and the particle size distribution suggested a size-dependent penetration mechanism (size threshold: 3.1 nm). The definite size-dependent uptake provides a new insight into the interactions between nanomaterials and living cells.

Graphical abstract: Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells

Supplementary files

Article information

Article type
Communication
Submitted
04 Feb 2018
Accepted
27 Mar 2018
First published
04 Apr 2018

Chem. Commun., 2018,54, 4557-4560

Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells

S. Ichikawa, N. Shimokawa, M. Takagi, Y. Kitayama and T. Takeuchi, Chem. Commun., 2018, 54, 4557 DOI: 10.1039/C8CC00977E

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