Issue 36, 2018
From the journal:

Chemical Communications

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor†

Clement Opoku-Temeng, ORCID logo ‡ab   Neetu Dayal,‡a   Delmis E. Hernandez,a   N. Nagannaa  and  Herman O. Sintim ORCID logo *ac  

* Corresponding authors

a Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA
E-mail: hsintim@purdue.edu
Tel: +1 (765) 496-6078

b Graduate Program in Biochemistry, University of Maryland, College Park, MD 20742, USA

c Center for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA

Abstract

Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines.

Graphical abstract: Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor

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Article information

DOI
https://doi.org/10.1039/C8CC01154K
Article type
Communication
Submitted
09 Feb 2018
Accepted
29 Mar 2018
First published
29 Mar 2018

Chem. Commun., 2018,54, 4521-4524

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Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor

C. Opoku-Temeng, N. Dayal, D. E. Hernandez, N. Naganna and H. O. Sintim, Chem. Commun., 2018, 54, 4521 DOI: 10.1039/C8CC01154K

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