Issue 32, 2018

Regioselectivity inversion tuned by iron(iii) salts in palladium-catalyzed carbonylations

Abstract

Impactful regioselectivity control is crucial for cost-effective chemical synthesis. By using cheap and abundant iron(III) salts, the hydroxycarbonylations of both aromatic and aliphatic alkenes were significantly enhanced in both reactivity and selectivity (iso/n or n/iso up to >99 : 1). Moreover, Pd-catalyzed carbonylation selectivity can be switched from branched to linear by using different Fe(III) salts. In addition, similar results were obtained for the carbonylation of secondary alcohols.

Graphical abstract: Regioselectivity inversion tuned by iron(iii) salts in palladium-catalyzed carbonylations

Supplementary files

Article information

Article type
Communication
Submitted
10 Feb 2018
Accepted
21 Mar 2018
First published
22 Mar 2018

Chem. Commun., 2018,54, 3967-3970

Regioselectivity inversion tuned by iron(III) salts in palladium-catalyzed carbonylations

Z. Huang, Y. Cheng, X. Chen, H. Wang, C. Du and Y. Li, Chem. Commun., 2018, 54, 3967 DOI: 10.1039/C8CC01190G

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