Issue 35, 2018
From the journal:

Chemical Communications

Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation†

Lei Xu,a   Qi Zhang,b   Qiang Xie,c   Bei Huang,a   Jian-Jun Dai, ORCID logo a   Jun Xu ORCID logo *a  and  Hua-Jian Xu ORCID logo *a  

* Corresponding authors

a School of Biology and Medical Engineering, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei University of Technology Hefei, P. R. China
E-mail: junxu@hfut.edu.cn, hjxu@hfut.edu.cn

b Institute of Industry & Equipment Technology, Hefei University of Technology Hefei, P. R. China

c PET-CT Center, The First Affiliated Hospital of USTC, Hefei, P. R. China

Abstract

An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive β-F elimination and C–F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of α-trifluoromethyl ketones as building blocks by C–F bond activation.

Graphical abstract: Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation

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Article information

DOI
https://doi.org/10.1039/C8CC01568F
Article type
Communication
Submitted
26 Feb 2018
Accepted
26 Mar 2018
First published
27 Mar 2018

Chem. Commun., 2018,54, 4406-4409

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Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation

L. Xu, Q. Zhang, Q. Xie, B. Huang, J. Dai, J. Xu and H. Xu, Chem. Commun., 2018, 54, 4406 DOI: 10.1039/C8CC01568F

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