An organocatalytic enantioselective direct α-heteroarylation of aldehydes with isoquinoline N-oxides

Abstract

A new protocol for the enantioselective direct α-heteroarylation of aldehydes with isoquinoline N-oxides, via chiral enamine catalysis, has been successfully developed. High enantiomeric excesses and moderate to good yields were achieved for a variety of α-heteroarylated aldehydes.