Issue 43, 2018
From the journal:

Chemical Communications

A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate†

Yu Fang,ab   Wen Shi, ORCID logo a   Yiming Hu,a   Xiaohua Li ORCID logo a  and  Huimin Ma ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: mahm@iccas.ac.cn

b University of the Chinese Academy of Sciences, Beijing 100049, China

Abstract

A new dual-function fluorescent probe is developed for detecting nitroreductase (NTR) and adenosine triphosphate (ATP) with different responses. Imaging application of the probe reveals that intracellular NTR and ATP display an adverse changing trend during a hypoxic process and ATP can serve as a new sign for cell hypoxia.

Graphical abstract: A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate

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Article information

DOI
https://doi.org/10.1039/C8CC02209G
Article type
Communication
Submitted
20 Mar 2018
Accepted
03 May 2018
First published
03 May 2018

Chem. Commun., 2018,54, 5454-5457

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A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate

Y. Fang, W. Shi, Y. Hu, X. Li and H. Ma, Chem. Commun., 2018, 54, 5454 DOI: 10.1039/C8CC02209G

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