Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.
V. Dhamodharan, Y. Nomura, M. Dwidar and Y. Yokobayashi, Chem. Commun., 2018, 54, 6181 DOI: 10.1039/C8CC02290A
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