Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

Abstract

Enantiomeric carbon dots (C-dots) synthesized from L-lysine or D-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, L-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.