Issue 55, 2018
From the journal:

Chemical Communications

A cocktail of 165Er(iii) and Gd(iii) complexes for quantitative detection of zinc using SPECT and MRI†

Kyangwi P. Malikidogo,a   Isidro Da Silva,b   Jean-François Morfin,a   Sara Lacerda, ORCID logo a   Laurent Barantin,c   Thierry Sauvage,b   Julien Sobilo,d   Stéphanie Lerondel,d   Éva Tóth ORCID logo *a  and  Célia S. Bonnet ORCID logo *a  

* Corresponding authors

a Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d’Orléans, Rue Charles Sadron, F-45071 Orléans 2, France
E-mail: celia.bonnet@cnrs.fr, eva.jakabtoth@cnrs.fr

b CEMHTI, CNRS UPR3079, Université d’Orléans, F-45071 Orléans 2, France

c UMR 1253, iBrain, Université de Tours, Tours, France

d Centre d’Imagerie du petit Animal, PHENOMIN-TAAM, CNRS UPS44, F-45071 Orléans 2, France

Abstract

We propose quantitative assessment of zinc by combining nuclear and MR imaging. We use a cocktail of a Gd3+-complex providing a Zn2+-dependent MRI response and its 165Er3+ analogue allowing for concentration assessment. 165Er is readily obtained in a cyclotron and purified, which is indispensable for successful quantification of metal ions.

Graphical abstract: A cocktail of 165Er(iii) and Gd(iii) complexes for quantitative detection of zinc using SPECT and MRI

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Article information

DOI
https://doi.org/10.1039/C8CC03407A
Article type
Communication
Submitted
26 Apr 2018
Accepted
16 May 2018
First published
16 May 2018

Chem. Commun., 2018,54, 7597-7600

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A cocktail of 165Er(III) and Gd(III) complexes for quantitative detection of zinc using SPECT and MRI

K. P. Malikidogo, I. Da Silva, J. Morfin, S. Lacerda, L. Barantin, T. Sauvage, J. Sobilo, S. Lerondel, É. Tóth and C. S. Bonnet, Chem. Commun., 2018, 54, 7597 DOI: 10.1039/C8CC03407A

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