Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework

Abstract

The first enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework constructed from (R)-2,2′-dihydroxy-1,1′-binaphthyl-6,6′-dicarboxylic acid has been developed. The reaction proceeded in high yields (∼96%) with excellent enantioselectivities (∼98% ee).