Issue 66, 2018

Reprogramming axial ligands facilitates the self-assembly of a platinum(iv) prodrug: overcoming drug resistance and safer in vivo delivery of cisplatin

Abstract

We herein reprogrammed axial ligands of platinum(IV) prodrugs, conferring the constructed prodrug entities with the ability to self-assemble in aqueous solution. Further cloaking of the PEG chain with Pluronic surfactant makes this nanoassembly (termed Pt(IV)-NP) suitable for systemic injection. Notably, Pt(IV)-NP significantly alleviated the toxicity of the parent cisplatin drug in vivo while preserving the pharmacological activity.

Graphical abstract: Reprogramming axial ligands facilitates the self-assembly of a platinum(iv) prodrug: overcoming drug resistance and safer in vivo delivery of cisplatin

Supplementary files

Article information

Article type
Communication
Submitted
10 May 2018
Accepted
25 Jul 2018
First published
25 Jul 2018

Chem. Commun., 2018,54, 9167-9170

Reprogramming axial ligands facilitates the self-assembly of a platinum(IV) prodrug: overcoming drug resistance and safer in vivo delivery of cisplatin

T. Fang, Z. Ye, J. Wu and H. Wang, Chem. Commun., 2018, 54, 9167 DOI: 10.1039/C8CC03763A

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