Issue 54, 2018
From the journal:

Chemical Communications

Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection†

Shuhei Kosono,a   Akihiro Kasai,a   Sumika Komaba,a   Teruhiko Matsubara,b   Toshinori Sato,b   Daisuke Takahashi ORCID logo *a  and  Kazunobu Toshima ORCID logo *a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
E-mail: dtak@applc.keio.ac.jp, toshima@applc.keio.ac.jp
Fax: +81 45-566-1576

b Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

Abstract

Among a series of chemically synthesized fucoidan derivatives (1–9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

Graphical abstract: Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

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Article information

DOI
https://doi.org/10.1039/C8CC03865A
Article type
Communication
Submitted
14 May 2018
Accepted
05 Jun 2018
First published
08 Jun 2018

Chem. Commun., 2018,54, 7467-7470

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Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

S. Kosono, A. Kasai, S. Komaba, T. Matsubara, T. Sato, D. Takahashi and K. Toshima, Chem. Commun., 2018, 54, 7467 DOI: 10.1039/C8CC03865A

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