Issue 60, 2018

Copper(i)-catalyzed N–H olefination of sulfonamides for N-sulfonyl enaminone synthesis

Abstract

This communication reports copper-catalyzed N–H olefination of sulfonamides for enaminone synthesis using saturated ketones as olefin sources. With TEMPO derivatives and O2 as oxidants, this method provided an efficient way to produce various enaminones in good yields. Mechanistic studies helped figure out the stable intermediates and develop novel methodologies for the difunctionalization of saturated ketones.

Graphical abstract: Copper(i)-catalyzed N–H olefination of sulfonamides for N-sulfonyl enaminone synthesis

Supplementary files

Article information

Article type
Communication
Submitted
02 Jun 2018
Accepted
04 Jul 2018
First published
05 Jul 2018

Chem. Commun., 2018,54, 8403-8406

Copper(I)-catalyzed N–H olefination of sulfonamides for N-sulfonyl enaminone synthesis

X. Liang, X. Huang, M. Xiong, K. Shen and Y. Pan, Chem. Commun., 2018, 54, 8403 DOI: 10.1039/C8CC04385J

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