Issue 65, 2018
From the journal:

Chemical Communications

An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells†

Zihe Yan,a   Jinyu Wang,a   Yanxin Zhang,b   Sichun Zhang, ORCID logo a   Juan Qiao ORCID logo *b  and  Xinrong Zhang*a  

* Corresponding authors

a Department of Chemistry, Beijing Key laboratory of Microanalytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China
E-mail: xrzhang@mail.tsinghua.edu.cn

b Department of Chemistry, Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
E-mail: qjuan@mail.tsinghua.edu.cn

Abstract

A novel photoluminescence lifetime probe (Ir-TB) has been developed for the detection and imaging of hCE2 in living cells. A large lifetime increase by around 300 ns after the enzymatic reaction makes it an ideal tool to distinguish hCE2-hydrolyzed probes from those non-hydrolyzed ones via PLIM for the first time.

Graphical abstract: An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells

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Article information

DOI
https://doi.org/10.1039/C8CC04481C
Article type
Communication
Submitted
12 Jun 2018
Accepted
16 Jul 2018
First published
18 Jul 2018

Chem. Commun., 2018,54, 9027-9030

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An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells

Z. Yan, J. Wang, Y. Zhang, S. Zhang, J. Qiao and X. Zhang, Chem. Commun., 2018, 54, 9027 DOI: 10.1039/C8CC04481C

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