Issue 64, 2018
From the journal:

Chemical Communications

Light-up RNA aptamer enabled label-free protein detection via a proximity induced transcription assay†

Zhan-Ming Ying,a   Hu-Yan Xiao,a   Hao Tang, ORCID logo *a   Ru-Qin Yu ORCID logo a  and  Jian-Hui Jiang ORCID logo *a  

* Corresponding authors

a Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: haotang@hnu.edu.cn, jianhuijiang@hnu.edu.cn
Fax: +86-731-88822872
Tel: +86-731-88822577

Abstract

A novel proximity induced transcription assay for highly sensitive protein detection based on protein mediated ligation of a DNA template with the transcription of a light-up RNA aptamer for signal amplification has been developed.

Graphical abstract: Light-up RNA aptamer enabled label-free protein detection via a proximity induced transcription assay

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Article information

DOI
https://doi.org/10.1039/C8CC04498H
Article type
Communication
Submitted
06 Jun 2018
Accepted
10 Jul 2018
First published
13 Jul 2018

Chem. Commun., 2018,54, 8877-8880

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Light-up RNA aptamer enabled label-free protein detection via a proximity induced transcription assay

Z. Ying, H. Xiao, H. Tang, R. Yu and J. Jiang, Chem. Commun., 2018, 54, 8877 DOI: 10.1039/C8CC04498H

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