Issue 60, 2018
From the journal:

Chemical Communications

Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 β-ketoester-functionalized indoles†

Sasa Wang,a   Miao Liu,a   Xinzheng Chen,a   Huifei Wang*a  and  Hongbin Zhai ORCID logo *abc  

* Corresponding authors

a The State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Shenzhen Graduate School of Peking University, Shenzhen 518055, China

b The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

c Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China

Abstract

A copper-catalyzed reaction of ethynyl benzoxazinanones with readily accessible β-ketoesters via a decarboxylative propargylation/hydroamination sequence has been developed. This protocol furnished a diverse range of C3 β-ketoester-functionalized indoles in good to excellent yields.

Graphical abstract: Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 β-ketoester-functionalized indoles

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Article information

DOI
https://doi.org/10.1039/C8CC04499F
Article type
Communication
Submitted
06 Jun 2018
Accepted
04 Jul 2018
First published
04 Jul 2018

Chem. Commun., 2018,54, 8375-8378

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Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 β-ketoester-functionalized indoles

S. Wang, M. Liu, X. Chen, H. Wang and H. Zhai, Chem. Commun., 2018, 54, 8375 DOI: 10.1039/C8CC04499F

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