Issue 83, 2018
From the journal:

Chemical Communications

Encoding function into polypeptide-oligonucleotide precision biopolymers†

Weina Liu,‡ab   Felix Boldt,‡ab   Yu Tokura,ab   Tao Wang,bc   Bikram Keshari Agrawalla,ab   Yuzhou Wu*ad  and  Tanja Weil ORCID logo *ab  

* Corresponding authors

a Max-Planck-Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
E-mail: weil@mpip-mainz.mpg.de

b Department of Inorganic Chemistry I, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany

c School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China

d Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Luoyu Road 1037, 430074 Hongshan, Wuhan, P. R. China
E-mail: wuyuzhou@hust.edu.cn

Abstract

We report a novel synthesis strategy to prepare precision polymers providing exact chain lengths, molecular weights and monomer sequences that allow post modifications by convenient DNA hybridization. Two grafted single strand DNA (ssDNA) side chains serve as a versatile platform for sequence-specific attachment of chromophores, proteins, cell-targeting peptide, and a Y-shape DNA linker. This approach resembles a LEGO®-type incorporation of functionalities to create functional biopolymers of high structure definition under mild conditions.

Graphical abstract: Encoding function into polypeptide-oligonucleotide precision biopolymers

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Article information

DOI
https://doi.org/10.1039/C8CC04725A
Article type
Communication
Submitted
13 Jun 2018
Accepted
21 Sep 2018
First published
26 Sep 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 11797-11800

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Encoding function into polypeptide-oligonucleotide precision biopolymers

W. Liu, F. Boldt, Y. Tokura, T. Wang, B. K. Agrawalla, Y. Wu and T. Weil, Chem. Commun., 2018, 54, 11797 DOI: 10.1039/C8CC04725A

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