Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release

Abstract

Supramolecular nanoparticles composed of doubly positively charged adamantane (ADA2+) and β-CD modified hyaluronic acid (HACD) were constructed. When the ester group in ADA2+ was hydrolyzed to a carboxyl group, the quaternary ammonium chain with a positive charge in ADA2+ converted to a “zwitterionic” structure, and the controlled binding and release of pDNA was realized.