Issue 66, 2018
From the journal:

Chemical Communications

Schiff base interaction tuned mesoporous organosilica nanoplatforms with pH-responsive degradability for efficient anti-cancer drug delivery in vivo†

Lei Liu,‡a   Chao Kong,‡b   Meng Huo,ac   Chengyu Liu,b   Liao Peng,a   Tian Zhao,a   Yen Wei,c   Feng Qian ORCID logo *b  and  Jinying Yuan ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Key Lab of Organic Optoelectronics & Molecular Engineering, Tsinghua University, Beijing 100084, China
E-mail: yuanjy@mail.tsinghua.edu.cn

b School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China
E-mail: qianfeng@biomed.tsinghua.edu.cn

c Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology of Ministry of Education, Department of Chemistry, and Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, P. R. China

Abstract

Chemically incorporating Schiff base interactions into silicate frameworks endows the obtained mesoporous organosilica based drug carriers with ultrafast pH-responsive degradability and efficient anti-cancer drug release kinetics, resulting in enhanced cancer therapy.

Graphical abstract: Schiff base interaction tuned mesoporous organosilica nanoplatforms with pH-responsive degradability for efficient anti-cancer drug delivery in vivo

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Article information

DOI
https://doi.org/10.1039/C8CC05043K
Article type
Communication
Submitted
24 Jun 2018
Accepted
23 Jul 2018
First published
23 Jul 2018

Chem. Commun., 2018,54, 9190-9193

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Schiff base interaction tuned mesoporous organosilica nanoplatforms with pH-responsive degradability for efficient anti-cancer drug delivery in vivo

L. Liu, C. Kong, M. Huo, C. Liu, L. Peng, T. Zhao, Y. Wei, F. Qian and J. Yuan, Chem. Commun., 2018, 54, 9190 DOI: 10.1039/C8CC05043K

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