Issue 65, 2018
From the journal:

Chemical Communications

Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH†

Sun Hae Ra Shin,a   Patrick T. McAninch,a   Ian M. Henderson,ab   Andrew Gomez,c   Adrienne C. Greene,a   Eric C. Carnesd  and  Walter F. Paxton ORCID logo *a  

* Corresponding authors

a Center for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185, USA
E-mail: wfpaxto@sandia.gov

b Omphalos Bioscience LLC, Albuquerque, NM 87110, USA

c Nano and Micro Sensors, Sandia National Laboratories, Albuquerque, NM 87185, USA

d Office of Research and Economic Development, University of Nebraska – Lincoln, Lincoln, NE 68588, USA

Abstract

Self-assembled giant polymer vesicles prepared from double-hydrophilic diblock copolymers, poly(ethylene oxide)-b-poly(acrylic acid) (PEO–PAA) show significant degradation in response to pH changes. Because of the switching behavior of the diblock copolymers at biologically-relevant pH environments (2 to 9), these polymer vesicles have potential biomedical applications as smart delivery vehicles.

Graphical abstract: Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH

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Article information

DOI
https://doi.org/10.1039/C8CC05155K
Article type
Communication
Submitted
29 Jun 2018
Accepted
19 Jul 2018
First published
27 Jul 2018

Chem. Commun., 2018,54, 9043-9046

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Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH

S. H. R. Shin, P. T. McAninch, I. M. Henderson, A. Gomez, A. C. Greene, E. C. Carnes and W. F. Paxton, Chem. Commun., 2018, 54, 9043 DOI: 10.1039/C8CC05155K

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