Issue 81, 2018

A multi-signal mitochondria-targeted fluorescent probe for real-time visualization of cysteine metabolism in living cells and animals

Abstract

In this study, we developed a multi-signal mitochondria-targeted fluorescent probe (NIR-Cys) for simultaneous detection of Cys and its metabolite, SO2. In the design of the probe, the acrylate group and the C[double bond, length as m-dash]C of the coumarin ring were used as the recognizing moiety for Cys and SO2, respectively. The probe exhibited high sensitivity, excellent specificity, and fast response. NIR-Cys was found to precisely target and visualize Cys metabolism in mitochondria of living cells with a multi-fluorescence signal. This probe is expected to be a useful tool for understanding Cys metabolism.

Graphical abstract: A multi-signal mitochondria-targeted fluorescent probe for real-time visualization of cysteine metabolism in living cells and animals

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2018
Accepted
29 Aug 2018
First published
30 Aug 2018

Chem. Commun., 2018,54, 11387-11390

A multi-signal mitochondria-targeted fluorescent probe for real-time visualization of cysteine metabolism in living cells and animals

X. Yang, W. Liu, J. Tang, P. Li, H. Weng, Y. Ye, M. Xian, B. Tang and Y. Zhao, Chem. Commun., 2018, 54, 11387 DOI: 10.1039/C8CC05418E

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