A general two-step one-pot synthesis process of ynones from α-keto acids and 1-iodoalkynes

Abstract

A general two-step one-pot synthesis process of ynones was developed by cycloaddition of α-keto acids and 1-iodoalkynes followed by a ring-opening reaction. Its easy conditions and novel mechanism endowed it with two distinctive advantages: iodine-atom bonded to C(sp²) remained intact and α-keto acids became a part of the triple bonds in ynones.