Issue 88, 2018
From the journal:

Chemical Communications

Metal-free cycloisomerizations of o-alkynylbiaryls†

Jingyi Zhang,a   Siqi Li,a   Yan Qiao,b   Cheng Peng,a   Xiao-Na Wang ORCID logo *a  and  Junbiao Chang*a  

* Corresponding authors

a Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China
E-mail: wangxn@zzu.edu.cn, changjunbiao@zzu.edu.cn

b School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China

Abstract

We describe a novel and highly efficient metal-free strategy to construct 9,9-disubstituted fluorenes and phenanthrenes via the TfOH-catalyzed cycloisomerizations of o-alkynylbiaryls. Notably, the significant effects of the electronic properties and steric hindrance of the alkyne terminus on the reaction selectivity have been observed.

Graphical abstract: Metal-free cycloisomerizations of o-alkynylbiaryls

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Article information

DOI
https://doi.org/10.1039/C8CC05484C
Article type
Communication
Submitted
07 Jul 2018
Accepted
11 Oct 2018
First published
11 Oct 2018

Chem. Commun., 2018,54, 12455-12458

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Metal-free cycloisomerizations of o-alkynylbiaryls

J. Zhang, S. Li, Y. Qiao, C. Peng, X. Wang and J. Chang, Chem. Commun., 2018, 54, 12455 DOI: 10.1039/C8CC05484C

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