Issue 77, 2018

An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection

Abstract

Herein, an adenosine triphosphate (ATP)-fueled nucleic acid signal amplification strategy based on toehold-mediated strand displacement (TMSD) and fluorescence resonance energy transfer (FRET) was proposed for highly sensitive detection of microRNA-21. More importantly, the target microRNA-21 could be regenerated with ATP as the fuel rather than a nucleotide segment in conventional approaches, which made the proposed strategy simple and efficient due to the high affinity and strength of the aptamer–target interaction.

Graphical abstract: An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection

Supplementary files

Article information

Article type
Communication
Submitted
09 Jul 2018
Accepted
04 Sep 2018
First published
05 Sep 2018

Chem. Commun., 2018,54, 10897-10900

An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection

Z. Wen, W. Liang, Y. Zhuo, C. Xiong, Y. Zheng, R. Yuan and Y. Chai, Chem. Commun., 2018, 54, 10897 DOI: 10.1039/C8CC05525D

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