Rhodium(iii)-catalyzed directed amidation of unactivated C(sp3)–H bonds to afford 1,2-amino alcohol derivatives

Abstract

A rhodium-catalyzed directed C(sp³)–H amidation to afford 1,2-amino alcohol oxime derivatives has been developed with good yields and a broad substrate scope. In previous methods for this type of reaction, 1-arylethan-1-ol oxime analogues were challenging substrates owing to strong competition from C(sp²)–H bond activation. This Rh-catalyzed C–H activation method overcomes the limitation of competitive C(sp²)–H bond activation.