Issue 69, 2018

A domino reaction of 2-isocyanophenyloxyacrylate and aryne to synthesize arenes with vicinal olefin and benzoxazole

Abstract

An unusual domino reaction of 2-isocyanophenyloxyacrylate and aryne has been disclosed. The present strategy experiences nucleophilic addition, Michael addition, carbon–oxygen cleavage, and cyclization, thus enabling the quick aryne vicinal difunctionalization by the installation of a benzoxazole and an olefin.

Graphical abstract: A domino reaction of 2-isocyanophenyloxyacrylate and aryne to synthesize arenes with vicinal olefin and benzoxazole

Supplementary files

Article information

Article type
Communication
Submitted
15 Jul 2018
Accepted
02 Aug 2018
First published
02 Aug 2018

Chem. Commun., 2018,54, 9611-9614

A domino reaction of 2-isocyanophenyloxyacrylate and aryne to synthesize arenes with vicinal olefin and benzoxazole

S. Su, J. Li, M. Sun, H. Zhao, Y. Chen and J. Li, Chem. Commun., 2018, 54, 9611 DOI: 10.1039/C8CC05735D

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