Mn–Fe layered double hydroxide nanosheets: a new photothermal nanocarrier for O2-evolving phototherapy

Abstract

Iron–manganese layered double hydroxide nanosheets were developed as an effective photothermal nanocarrier for loading a photosensitizer. The catalase-like activity enables the nanosheets to decompose H₂O₂ into O₂, overcoming tumor hypoxia and enhancing O₂-dependent photodynamic therapy (PDT). The combination of PDT and photothermal therapy (PTT) can almost completely eliminate tumor tissues.