Issue 76, 2018

A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers

Abstract

We report a novel biosensor platform based on competitive non-covalent interaction between ssDNA and a mass tag towards AuNPs, which detects PSA biomarkers sensitively, observed using MALDI MS. A detection limit of 57 pg mL−1 has been achieved, showing an improvement of two orders of magnitude compared to the traditional spectroscopic method.

Graphical abstract: A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers

Supplementary files

Article information

Article type
Communication
Submitted
27 Jul 2018
Accepted
17 Aug 2018
First published
18 Aug 2018

Chem. Commun., 2018,54, 10726-10729

A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers

J. Han, Y. Li, L. Zhan, J. Xue, J. Sun, C. Xiong and Z. Nie, Chem. Commun., 2018, 54, 10726 DOI: 10.1039/C8CC06100A

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