An anthraquinone–enzyme–peptide hybrid as a photo-switchable enzyme

Shota Sotokawa; Takashi Kitamura; Daisuke Takahashi; Kazunobu Toshima

doi:10.1039/C8CC06130K

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An anthraquinone–enzyme–peptide hybrid as a photo-switchable enzyme†

Shota Sotokawa,^a Takashi Kitamura,^a Daisuke Takahashi

^a and Kazunobu Toshima

*^a

Author affiliations

* Corresponding authors

^a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
E-mail: toshima@applc.keio.ac.jp
Fax: +81 45-566-1576

Abstract

A purpose-designed anthraquinone–horseradish peroxidase (HRP)–cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.

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Article information

DOI: https://doi.org/10.1039/C8CC06130K
Article type: Communication
Submitted: 27 Jul 2018
Accepted: 28 Aug 2018
First published: 29 Aug 2018

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Chem. Commun., 2018,54, 10614-10617

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An anthraquinone–enzyme–peptide hybrid as a photo-switchable enzyme

S. Sotokawa, T. Kitamura, D. Takahashi and K. Toshima, Chem. Commun., 2018, 54, 10614 DOI: 10.1039/C8CC06130K

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Chemical Communications

An anthraquinone–enzyme–peptide hybrid as a photo-switchable enzyme†

Abstract

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An anthraquinone–enzyme–peptide hybrid as a photo-switchable enzyme

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