Issue 85, 2018

Conformational restraint as a strategy for navigating towards lysosomes

Abstract

Using the conformational restraint strategy, we developed a hydrazonate-derived coumarin into a lysosome targeting probe for imaging native formaldehyde at the subcellular level. Using this probe, we observed the overproduction of formaldehyde in lysosomes when cells were treated with endoplasmic reticulum (ER) stress inducers, suggesting the involvement of formaldehyde in protein misfolding.

Graphical abstract: Conformational restraint as a strategy for navigating towards lysosomes

Supplementary files

Article information

Article type
Communication
Submitted
28 Jul 2018
Accepted
30 Aug 2018
First published
30 Aug 2018

Chem. Commun., 2018,54, 12010-12013

Conformational restraint as a strategy for navigating towards lysosomes

X. Liang, J. Cheng, S. Qin, L. Shao, M. Huang, G. Wang, Y. Han, F. Han and X. Li, Chem. Commun., 2018, 54, 12010 DOI: 10.1039/C8CC06155F

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