Issue 98, 2018
From the journal:

Chemical Communications

Photoactivatable platinum anticancer complex can generate tryptophan radicals†

Claudio Vallotto, ORCID logo a   Evyenia Shaili,b   Huayun Shi,b   Jennifer S. Butler,b   Christopher J. Wedge, ORCID logo ac   Mark E. Newton*a  and  Peter J. Sadler ORCID logo *b  

* Corresponding authors

a Department of Physics, University of Warwick, Coventry, UK
E-mail: m.e.newton@warwick.ac.uk

b Department of Chemistry, University of Warwick, Coventry, UK
E-mail: p.j.sadler@warwick.ac.uk

c Department of Chemical Sciences, University of Huddersfield, Queensgate, Huddersfield, UK

Abstract

L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.

Graphical abstract: Photoactivatable platinum anticancer complex can generate tryptophan radicals

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Article information

DOI
https://doi.org/10.1039/C8CC06496B
Article type
Communication
Submitted
10 Aug 2018
Accepted
24 Oct 2018
First published
23 Nov 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 13845-13848

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Photoactivatable platinum anticancer complex can generate tryptophan radicals

C. Vallotto, E. Shaili, H. Shi, J. S. Butler, C. J. Wedge, M. E. Newton and P. J. Sadler, Chem. Commun., 2018, 54, 13845 DOI: 10.1039/C8CC06496B

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