Issue 87, 2018
From the journal:

Chemical Communications

p-Toluenesulfonic acid catalysed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centres†

Shi-Zhong Tang,a   Hong-Li Bian,a   Zong-Song Zhan,a   Meng-En Chen,a   Jian-Wei Lv,a   Shaolei Xiea  and  Fu-Min Zhang ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, P. R. China
E-mail: zhangfm@lzu.edu.cn

b Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, P. R. China

Abstract

A p-toluenesulfonic acid catalyzed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centers has been developed, featuring a broad substrate scope, environmentally benign reaction conditions, and operational simplicity.

Graphical abstract: p-Toluenesulfonic acid catalysed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centres

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Article information

DOI
https://doi.org/10.1039/C8CC06643D
Article type
Communication
Submitted
15 Aug 2018
Accepted
09 Oct 2018
First published
09 Oct 2018

Chem. Commun., 2018,54, 12377-12380

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p-Toluenesulfonic acid catalysed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centres

S. Tang, H. Bian, Z. Zhan, M. Chen, J. Lv, S. Xie and F. Zhang, Chem. Commun., 2018, 54, 12377 DOI: 10.1039/C8CC06643D

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