Issue 93, 2018
From the journal:

Chemical Communications

CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation†

Takeshi Yamada, ORCID logo a   Shouta Miki,a   Lu Ni ORCID logo a  and  Kazuhiko Nakatani ORCID logo *a  

* Corresponding authors

a The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan
E-mail: nakatani@sanken.osaka-u.ac.jp

Abstract

A new DNA binding small molecule, NCD-CC is reported. NCD-CC has a NCD domain, which recognizes the G–G mismatch in a CGG/CGG triad, and a cysteinylcystein (CC) moiety. Dimerization of NCD-CC through intermolecular disulfide bond formation was accelerated in the presence of CGG repeat DNA.

Graphical abstract: CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

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Article information

DOI
https://doi.org/10.1039/C8CC06757K
Article type
Communication
Submitted
20 Aug 2018
Accepted
25 Sep 2018
First published
25 Sep 2018

Chem. Commun., 2018,54, 13072-13075

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CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

T. Yamada, S. Miki, L. Ni and K. Nakatani, Chem. Commun., 2018, 54, 13072 DOI: 10.1039/C8CC06757K

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