Dual-modal in vivo fluorescence and photoacoustic imaging using a heterodimeric peptide

Jing Chen; Zhenghong Gao; Gaoming Li; Thomas D. Wang

doi:10.1039/C8CC06774K

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Dual-modal in vivo fluorescence and photoacoustic imaging using a heterodimeric peptide†

Jing Chen,

^a Zhenghong Gao,^a Gaoming Li^b and Thomas D. Wang

*^abc

Author affiliations

* Corresponding authors

^a Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

^b Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA

^c Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
E-mail: thomaswa@umich.edu
Fax: +1-734-647-7950
Tel: +1-734-936-1228

Abstract

A heterodimeric peptide labeled with IRDye800 is used to perform dual-modal imaging of human esophageal xenograft tumors in vivo. Fluorescence and photoacoustic images provide complementary visualization of tumor dimensions in planar and sagittal views, respectively, demonstrating promise for targeted cancer diagnosis and staging.

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Article information

DOI: https://doi.org/10.1039/C8CC06774K
Article type: Communication
Submitted: 21 Aug 2018
Accepted: 08 Oct 2018
First published: 08 Oct 2018

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Chem. Commun., 2018,54, 13196-13199

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Dual-modal in vivo fluorescence and photoacoustic imaging using a heterodimeric peptide

J. Chen, Z. Gao, G. Li and T. D. Wang, Chem. Commun., 2018, 54, 13196 DOI: 10.1039/C8CC06774K

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Chemical Communications

Dual-modal in vivo fluorescence and photoacoustic imaging using a heterodimeric peptide†

Abstract

Supplementary files

Article information

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Dual-modal in vivo fluorescence and photoacoustic imaging using a heterodimeric peptide

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