Issue 84, 2018
From the journal:

Chemical Communications

Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy†

Yu Zhu,ab   Wenhai Lin, ORCID logo *bc   Xin Wang,d   Wei Zhang,bc   Li Chen ORCID logo *a  and  Zhigang Xie ORCID logo *b  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, P. R. China
E-mail: chenl686@nenu.edu.cn

b State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, P. R. China
E-mail: xiez@ciac.ac.cn, kid@ciac.ac.cn

c University of Chinese Academy of Sciences, Beijing 100049, P. R. China

d Department of Thyroid Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, P. R. China

Abstract

In this work, we decorated the surface of MSNs by a one-pot Passerini reaction using near-infrared fluorescence BODIPY and poly(ethylene glycol) with an aldehyde group (PEG-CHO) for the first time. Doxorubicin (Dox) was loaded to demonstrate the reduction response. The formed MSNs neatly integrate chemotherapy, photothermal therapy and near-infrared fluorescence (NIRF) imaging.

Graphical abstract: Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy

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Article information

DOI
https://doi.org/10.1039/C8CC07106C
Article type
Communication
Submitted
03 Sep 2018
Accepted
22 Sep 2018
First published
25 Sep 2018

Chem. Commun., 2018,54, 11921-11924

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Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy

Y. Zhu, W. Lin, X. Wang, W. Zhang, L. Chen and Z. Xie, Chem. Commun., 2018, 54, 11921 DOI: 10.1039/C8CC07106C

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