Chiral Lewis acid-promoted enantioselective α-alkylation of β-ketoamides with phenyliodonium ylide was developed. In the presence of a chiral N,N′-dioxide/Ni(II) complex, the corresponding 1,4-dicarbonyl compounds were obtained with good results (up to 91% yield and 97% ee). Control experiments and EPR studies supported a radical process.
J. Guo, X. Liu, C. He, F. Tan, S. Dong and X. Feng, Chem. Commun., 2018, 54, 12254 DOI: 10.1039/C8CC07140C
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