Issue 88, 2018
From the journal:

Chemical Communications

Lighting up alkaline phosphatase in drug-induced liver injury using a new chemiluminescence resonance energy transfer nanoprobe†

Xueting Liu,‡a   Nannan Fan,‡a   Lijie Wu,a   Chuanchen Wu,a   Yongqing Zhou,a   Ping Li*a  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Biomedical Sciences, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn, lip@sdnu.edu.cn

Abstract

We present a new nanoprobe based on chemiluminescence resonance energy transfer for in vivo imaging of drug-induced alkaline phosphatase (ALP). This probe exhibits the perfect degrees of high sensitivity and specificity for real-time monitoring of ALP levels to directly evaluate drug-induced liver injury.

Graphical abstract: Lighting up alkaline phosphatase in drug-induced liver injury using a new chemiluminescence resonance energy transfer nanoprobe

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Article information

DOI
https://doi.org/10.1039/C8CC07211F
Article type
Communication
Submitted
05 Sep 2018
Accepted
05 Oct 2018
First published
11 Oct 2018

Chem. Commun., 2018,54, 12479-12482

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Lighting up alkaline phosphatase in drug-induced liver injury using a new chemiluminescence resonance energy transfer nanoprobe

X. Liu, N. Fan, L. Wu, C. Wu, Y. Zhou, P. Li and B. Tang, Chem. Commun., 2018, 54, 12479 DOI: 10.1039/C8CC07211F

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