Issue 95, 2018
From the journal:

Chemical Communications

Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment†

Chongchong Wang,‡a   Yanqing Li,‡a   Xianqing Shi,a   Jiahong Zhou,a   Lin Zhou ORCID logo *a  and  Shaohua Wei ORCID logo *a  

* Corresponding authors

a College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing (210023), China
E-mail: zhoulin@njnu.edu.cn, shwei@njnu.edu.cn

Abstract

The carbon monoxide (CO)-carrying palladium nanosheet (PdNS-CO) was exploited as a photothermally triggered donor of CO. Irradiating material containing PdNS-CO with 808 nm-wavelength light caused a rapid heating of the material, triggering a release of CO. The enhanced permeability and retention (EPR) effect was found to be improved by such released CO and resulted in an increase in the accumulation of PdNS-CO at tumors and hence promoted its use in photothermal therapy (PTT) using a low laser power density.

Graphical abstract: Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

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Article information

DOI
https://doi.org/10.1039/C8CC07873D
Article type
Communication
Submitted
02 Oct 2018
Accepted
01 Nov 2018
First published
02 Nov 2018

Chem. Commun., 2018,54, 13403-13406

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Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

C. Wang, Y. Li, X. Shi, J. Zhou, L. Zhou and S. Wei, Chem. Commun., 2018, 54, 13403 DOI: 10.1039/C8CC07873D

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