Issue 91, 2018

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

Abstract

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ1–40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating the reduced neurotoxicity of nanodisc-bound Aβ oligomers are also reported.

Graphical abstract: Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

Supplementary files

Article information

Article type
Communication
Submitted
03 Oct 2018
Accepted
22 Oct 2018
First published
22 Oct 2018

Chem. Commun., 2018,54, 12883-12886

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

B. R. Sahoo, T. Genjo, M. Bekier, S. J. Cox, A. K. Stoddard, M. Ivanova, K. Yasuhara, C. A. Fierke, Y. Wang and A. Ramamoorthy, Chem. Commun., 2018, 54, 12883 DOI: 10.1039/C8CC07921H

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