Issue 3, 2018
From the journal:

Dalton Transactions

Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents†

Zhizhou Yue,a   Han Wang,a   David J. Bowers,a   Min Gao,b   Morgan Stilgenbauer,a   Frederick Nielsen,a   Jacob T. Shelleyc  and  Yao-Rong Zheng ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Kent State University, 224 Williams Hall, Kent, Ohio 44242, USA
E-mail: yzheng7@kent.edu

b Liquid Crystal Institute, Kent State University, 1425 Lefton Esplanade, Kent, Ohio 44242, USA

c Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 228 Cogswell Laboratory, 110 8th Street, Troy, NY, 12180 USA

Abstract

We present a novel design to use metal–organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(IV) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host–guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.

Graphical abstract: Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents

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Article information

DOI
https://doi.org/10.1039/C7DT03537C
Article type
Communication
Submitted
20 Sep 2017
Accepted
07 Dec 2017
First published
07 Dec 2017

Dalton Trans., 2018,47, 670-674

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Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents

Z. Yue, H. Wang, D. J. Bowers, M. Gao, M. Stilgenbauer, F. Nielsen, J. T. Shelley and Y. Zheng, Dalton Trans., 2018, 47, 670 DOI: 10.1039/C7DT03537C

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